The adrenal cortex and hemolysis. III. Peripheral blood cell reactions.

By J. D. FELDMAN, M. RACHMILEWITZ AND 0. STEIN I N THE COURSE OF STUDYING THE EFFECT of the adrenal cortex and its hormones omi hemolysis, a uniform pattern of beukocyte response was noted.’2 ‘ 13 The reaction consisted of marked leukocytosis, neutrophilia amid eosimiophibia throughout the period of red cell destruction. A search of the medical literature oh this aspect of hemolysis revealed a few isolated amid brief remarks that various types of hemolytic amiemia were accompanied by leukocytosis.2 . 24 , 28 . 35 The present investigation was initiated to study more thoroughly the pattern of leukocyte response during hemolysis. To elucidate the mechanism of this response the peripheral blood reactiomis were also observed iii animals with hemorrhagic anemia, in adrenalectomized and ACTH-treated rats, amid in animals subj ected to ‘ ‘stressing’ ‘ procedures.